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The MIVEGEC develops approaches to understand the functional and structural genomics of pathogens, as well as exploring the roles of segregation, replication and transcription for chromosomes . Other interests include the mechanisms (or lack of mechanisms) involved in regulating gene expression in ancestral eukaryotes (e.g. Leishmania, Trypanosoma), particularly those implicated in intracellular transport and the dynamics of microtubules during mitosis. The aim of these studies is to identify their role during the cell cycle and to understand the variation in ploidy frequently observed in these organisms, for example, as in the Leishmania.

Concerning vectors, in particular mosquitoes, we study the polymorphism of chromosome inversions using cytogenetics. Our emphasis is on the adaptive value of inversions and their role in the process of local adaptation and speciation. Different molecular markers (SNPs, microsatellites, transposons) and morphometrics are used to study the phylogeny, phylo-geography and population genetics of the main arthropod vectors of disease (mosquitoes, triatomes, ticks, sandflies), as well their systematics and evolutionary dynamics.

The group also studies the mechanisms of reproduction in protozoan parasites, including the quantification of selfing within populations of Plasmodium and Leishmania, in relation to their evolutionary consequences (e.g. adaptation, speciation) and potential role in public health (e.g. the evolution of resistance or virulence).