Votre navigateur est trop ancien pour afficher correctement ce site. Ceci en est la version simplifiée.

 

 

Surname : BRAVO
Name : Ignacio
Team : SEE
Grade : DR2
Email address : This email address is being protected from spambots. You need JavaScript enabled to view it.
Fax : (+33) 4 67 41 62 99
Office : 316
Locality : IRD Montpellier
Employer : CNRS
Theme : Chronic infections, infections and cancer, virus evolution, codon usage preferences

Publications :

Bedhomme S, Pantoja DP, Bravo IG (2017) Plasmid and clonal interference during post horizontal gene transfer evolution. Molecular Ecology 26: 1832-1847 doi

Nicolás-Párraga S, Alemany L, de Sanjosé S, Bosch FX, Bravo IG, RIS HPV TT and HPV VVAP study groups (2017) Differential HPV16 variant distribution in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma. International Journal of Cancer 140: 2092-2100 doi

Pimenoff VN, de Oliveira CM, Bravo IG (2017) Transmission between archaic and modern human ancestors during the evolution of the oncogenic human papillomavirus 16. Molecular Biology and Evolution 34: 4-19 doi

Félez-Sánchez M, Vergara M, de Sanjosé S, Castellsague X, Alemany L, Bravo IG, Grp Vvapo Ris Hpv Tt Study (2016) Searching beyond the usual papillomavirus suspects in squamous carcinomas of the vulva, penis and head and neck. Infection, Genetics and Evolution 45: 198-204 doi

Mengual-Chulá B, Bedhomme S, Lafforgue G, Elena SF, Bravo IG (2016) Assessing parallel gene histories in viral genomes. BMC Evolutionary Biology 16: 32 doi

Nicolás-Párraga S, Gandini C, Pimenoff VN, Alemany L, de Sanjose S, Bosch FX, Bravo IG, Ris Hpv TT, Grp Hpv Vvap Study (2016) HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus. Cancer Medicine 5: 2909-2919 doi

Zhang ZL, Gu QY, Vasudevan AAJ, Hain A, Kloke BP, Hasheminasab S, Mulnaes D, Sato K, Cichutek K, Haussinger D, Bravo IG, Smits SHJ, Gohlke H, Münk C (2016) Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors. Retrovirology 13: 46 doi

Alemany L, Saunier M, Alvarado-Cabrero I, Quiros B, Salmeron J, Shin HR, Pirog EC, Guimera N, Hernandez-Suarez G, Felix A, Clavero O, Lloveras B, Kasamatsu E, Goodman MT, Hernandez BY, Laco J, Tinoco L, Geraets DT, Lynch CF, Mandys V, Poljak M, Jach R, Verge J, Clavel C, Ndiaye C, Klaustermeier J, Cubilla A, Castellsague X, Bravo IG, Pawlita M, Quint WG, Munoz N, Bosch FX, de Sanjose S, Grp Hpv Vvap Study (2015) Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide. International Journal of Cancer 136: 98-107 doi

de Oliveira CM, Bravo IG, Souza NCS, Genta LND, Fregnani JHTG, Tacla M, Carvalho JP, Longatto A, Levi JE (2015) High-level of viral genomic diversity in cervical cancers: a brazilian study on human papillomavirus type 16. Infection, Genetics and Evolution 34: 44-51 doi

Felez-Sanchez M, Trosemeier JH, Bedhomme S, Gonzalez-Bravo MI, Kamp C, Bravo IG (2015) Cancer, warts, or asymptomatic infections: clinical presentation matches codon usage preferences in human papillomaviruses. Genome Biology and Evolution 7: 2117-2135 doi

Alemany L, de Sanjose S, Tous S, Quint W, Vallejos C, Shin HR, Bravo LE, Alonso P, Lima MA, Guimera N, Klaustermeier J, Llombart-Bosch A, Kasamatsu E, Tatti SA, Felix A, Molina C, Velasco J, Lloveras B, Clavero O, Lerma E, Laco J, Bravo IG, Guarch R, Pelayo A, Ordi J, Andujar M, Sanchez GI, Castellsague X, Munoz N, Bosch FX, Grp Ris Hpv Tt Study (2014) Time trends of human papillomavirus types in invasive cervical cancer, from 1940 to 2007. International Journal of Cancer 135: 88-95 doi

Alemany L, Saunier M, Tinoco L, Quiros B, Alvarado-Cabrero I, Alejo M, Joura EA, Maldonado P, Klaustermeier J, Salmeron J, Bergeron C, Petry KU, Guimera N, Clavero O, Murillo R, Clavel C, Wain V, Geraets DT, Jach R, Cross P, Carrilho C, Molina C, Shin HR, Mandys V, Nowakowski AM, Vidal A, Lombardi L, Kitchener H, Sica AR, Magana-Leon C, Pawlita M, Quint W, Bravo IG, Munoz N, de Sanjose S, Bosch FX, Grp Hpv Vvap Study (2014) Large contribution of human papillomavirus in vaginal neoplastic lesions: a worldwide study in 597 samples. European Journal of Cancer 50: 2846-2854 doi

Garcia-Perez R, Ibanez C, Godinez JM, Arechiga N, Garin I, Perez-Suarez G, de Paz O, Juste J, Echevarria JE, Bravo IG (2014) Novel papillomaviruses in free-ranging Iberian bats: no virus-host co-evolution, no strict host specificity, and hints for recombination. Genome Biology and Evolution 6: 94-104 doi

Godinez JM, Nicolas-Parraga S, Pimenoff VN, Mengual-Chulia B, Munoz N, Bosch FX, Sanchez GI, McCloskey J, Bravo IG (2014) Phylogenetically related, clinically different: human papillomaviruses 6 and 11 variants distribution in genital warts and in laryngeal papillomatosis. Clinical Microbiology and Infection 20: O406-O413 doi

Ibanez R, Felez-Sanchez M, Godinez JM, Guardia C, Caballero E, Juve R, Combalia N, Bellosillo B, Cuevas D, Moreno-Crespi J, Pons L, Autonell J, Gutierrez C, Ordi J, de Sanjose S, Bravo IG (2014) Interlaboratory reproducibility and proficiency testing within the human papillomavirus cervical cancer screening program in Catalonia, Spain. Journal of Clinical Microbiology 52: 1511-1518 doi

Mengual-Chulia B, Domenis L, Robetto S, Bravo IG (2014) A novel papillomavirus isolated from a nasal neoplasia in an Italian free-ranging chamois (rupicapra r. rupicapra). Veterinary Microbiology 172: 108-119 doi

Pelchovich G, Nadejda S, Dana A, Tuller T, Bravo IG, Gophna U (2014) Ribosomal mutations affecting the translation of genes that use non-optimal codons. FEBS Journal 281: 3701-3718 doi

de Sanjose S, Alemany L, Ordi J, Tous S, Alejo M, Bigby SM, Joura EA, Maldonado P, Laco J, Bravo IG, Vidal A, Guimera N, Cross P, Wain GV, Petry KU, Mariani L, Bergeron C, Mandys V, Sica AR, Felix A, Usubutun A, Seoud M, Hernandez-Suarez G, Nowakowski AM, Wilson G, Dalstein V, Hampl M, Kasamatsu ES, Lombardi LE, Tinoco L, Alvarado-Cabrero I, Perrotta M, Bhatla N, Theodoros A, Lynch CF, Goodman MT, Shin HR, Viarheichyk H, Jach R, Cruz MOLE, Velasco J, Molina C, Bornstein J, Ferrera A, Domingo EJ, Cheng-Yang C, Banjo AF, Castellsague X, Pawlita M, Lloveras B, Quint WGV, Munoz N, Bosch FX, Grp Hpv Vvap Study (2013) Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva. European Journal of Cancer 49: 3450-3461 doi

Garcia-Perez R, Gottschling M, Wibbelt G, Bravo IG (2013) Multiple evolutionary origins of bat papillomaviruses. Veterinary Microbiology 165: 51-60 doi

Godinez JM, Heideman DAM, Gheit T, Alemany L, Snijders PJF, Tommasino M, Meijer C, de Sanjose S, Bosch FX, Bravo IG (2013) Differential presence of papillomavirus variants in cervical cancer: an analysis for HPV33, HPV45 and HPV58. Infection, Genetics and Evolution 13: 96-104 doi

Guimera N, Lloveras B, Lindeman J, Alemany L, van de Sandt M, Alejo M, Hernandez-Suarez G, Bravo IG, Molijn A, Jenkins D, Cubilla A, Munoz N, de Sanjose S, Bosch FX, Quint W, Grp Ris Hpv Tt Hpv Vvapo Study (2013) The occasional role of low-risk human papillomaviruses 6, 11, 42, 44, and 70 in anogenital carcinoma defined by laser capture microdissection/PCR methodology results from a global study. American Journal of Surgical Pathology 37: 1299-1310

Jacquin E, Baraquin A, Ramanah R, Carcopino X, Morel A, Valmary-Degano S, Bravo IG, de Sanjose S, Riethmuller D, Mougin C, Pretet JL (2013) Methylation of human papillomavirus type 16 CpG sites at E2-binding site 1 (E2BS1), E2BS2, and the Sp1-binding site in cervical cancer samples as determined by high-resolution melting analysis-PCR. Journal of Clinical Microbiology 51: 3207-3215 doi

Armitage SAO, Freiburg RY, Kurtz J, Bravo IG (2012) The evolution of Dscam genes across the arthropods. BMC Evolutionary Biology 12: 53 doi

Bogaert L, Willemsen A, Vanderstraeten E, Bracho MA, De Baere C, Bravo IG, Martens (2012) EcPV2 DNA in equine genital squamous cell carcinomas and normal genital mucosa. Veterinary Microbiology 158: 33-41 doi

Doorbar J, Quint W, Banks L, Bravo IG, Stoler M, Broker TR, Stanley M (2012) The biology and life-cycle of human papillomaviruses. Vaccine 30: F55-F70 doi

Mengual-Chulia B, Garcia-Perez R, Gottschling M, Nindl I, Bravo IG (2012) Novel animal papillomavirus sequences and accurate phylogenetic placement. Molecular Phylogenetics and Evolution 65: 883-891 doi

Munk C, Willemsen A, Bravo IG (2012) An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals. BMC Evolutionary Biology 12: 71 doi

Bravo IG, de Sanjose S, Gottschling M (2011) Papillomaviruses and darwinian classification: response to van Doorslaer et al. Trends in Microbiology 19: 50-51 doi

Dorrschuck E, Fischer N, Bravo IG, Hanschmann KM, Kuiper H, Spotter A, Moller R, Cichutek K, Munk C, Tonjes RR (2011) Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases. Journal of Virology 85: 3842-3857 doi

Godinez JM, Tous S, Baixeras N, Moreno-Crespi J, Alejo M, Lejeune M, Bravo IG, Bosch FX, de Sanjose S (2011) Performance of the digene LQ, RH and PS HPVs genotyping systems on clinical samples and comparison with HC2 and PCR-based linear array. Infectious Agents and Cancer 6: Unsp 23 doi

Gottschling M, Bravo IG, Schulz E, Bracho MA, Deaville R, Jepson PD, Van Bressem MF, Stockfleth E, Nindl I (2011) Modular organizations of novel cetacean papillomaviruses. Molecular Phylogenetics and Evolution 59: 34-42 doi

Gottschling M, Goker M, Stamatakis A, Bininda-Emonds ORP, Nindl I, Bravo IG (2011) Quantifying the phylodynamic forces driving papillomavirus evolution. Molecular Biology and Evolution 28: 2101-2113 doi

Kovanda A, Kocjan BJ, Luzar B, Bravo IG, Poljak M (2011) Characterization of novel cutaneous human papillomavirus genotypes HPV-150 and HPV-151. PLoS One 6: e22529 doi

Vanderstraeten E, Bogaert L, Bravo IG, Martens A (2011) EcPV2 DNA in equine squamous cell carcinomas and normal genital and ocular mucosa. Veterinary Microbiology 147: 292-299 doi

Amoros-Moya D, Bedhomme S, Hermann M, Bravo IG (2010) Evolution in regulatory regions rapidly compensates the cost of nonoptimal codon usage. Molecular Biology and Evolution 27: 2141-2151 doi

Bravo IG, de Sanjose S, Gottschling M (2010) The clinical importance of understanding the evolution of papillomaviruses. Trends in Microbiology 18: 432-438 doi

Kamp C, Wolf T, Bravo IG, Kraus B, Krause B, Neumann B, Winskowsky G, Thielen A, Werner A, Schnierle BS (2010) Decreased HIV diversity after allogeneic stem cell transplantation of an HIV-1 infected patient: a case report. Virology Journal 7: 55 doi

Reinartz A, Ehling J, Franz S, Simon V, Bravo IG, Tessmer C, Zentgraf H, Lyer S, Schneider U, Koster J, Raupach K, Kammerer E, Klaus C, Tischendorf JJW, Kopitz J, Alonso A, Gassler N (2010) Small intestinal mucosa expression of putative chaperone fls485. BMC Gastroenterology 10: 27 doi

Schadlich L, Senger T, Gerlach B, Mucke N, Klein C, Bravo IG, Muller M, Gissmann L (2009) Analysis of modified human papillomavirus type 16 L1 capsomeres: the ability to assemble into larger particles correlates with higher immunogenicity. Journal of Virology 83: 7690-7705 doi

Schulz E, Gottschling M, Bravo IG, Wittstatt U, Stockfleth E, Nindl I (2009) Genomic characterization of the first insectivoran papillomavirus reveals an unusually long, second non-coding region and indicates a close relationship to betapapillomavirus. Journal of General Virology 90: 626-633 doi

Zielonka J, Bravo IG, Marino D, Conrad E, Perkovic M, Battenberg M, Cichutek K, Munk C (2009) Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases. Journal of Virology 83: 7547-7559 doi

Lewis C, Baro MF, Marques M, Gruner M, Alonso A, Bravo IG (2008) The first hydrophobic region of the HPV16 E5 protein determines protein cellular location and facilitates anchorage-independent growth. Virology Journal 5: 30 doi

Michael KM, Waterboer T, Sehr P, Rother A, Reidel U, Boeing H, Bravo IG, Schlehofer J, Gartner BC, Pawlita M (2008) Seroprevalence of 34 human papillomavirus types in the German general population. PLoS Pathogens 4: e1000091 doi

Munk C, Beck T, Zielonka J, Hotz-Wagenblatt A, Chareza S, Battenberg M, Thielebein J, Cichutek K, Bravo IG, O'Brien SJ, Lochelt M, Yuhki N (2008) Functions, structure, and read-through alternative splicing of feline APOBEC3 genes. Genome Biology 9: R48 doi

Nafz J, Schafer K, Chen SF, Bravo IG, Ibberson M, Nindl I, Stockfleth E, Rosl F (2008) A novel rodent papillomavirus isolated from anogenital lesions in its natural host. Virology 374: 186-197 doi

Puigbo P, Bravo IG, Garcia-Vallve S (2008) CAIcal: a combined set of tools to assess codon usage adaptation. Biology Direct 3: 38 doi

Puigbo P, Bravo IG, Garcia-Vallve S (2008) E-CAI: a novel server to estimate an expected value of codon adaptation index (eCAI). BMC Bioinformatics 9: 65 doi

Bravo IG, Alonso (2007) Phylogeny and evolution of papillomaviruses based on the E1 and E2 proteins. Virus Genes 34: 249-262 doi

Gassler N, Roth W, Funke B, Schneider A, Herzog F, Tischendorf JJW, Grund K, Penzel R, Bravo IG, Mariadason J, Ehemann V, Sykora J, Haas TL, Walczak H, Ganten T, Zentgraf H, Erb P, Alonso A, Autschbach F, Schirmacher P, Knuchel R, Kopitz J (2007) Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. Gastroenterology 133: 587-598 doi

Gottschling M, Stamatakis A, Nindl I, Stockfleth E, Alonso A, Bravo IG (2007) Multiple evolutionary mechanisms drive papillomavirus diversification. Molecular Biology and Evolution 24: 1242-1258 doi

Gruener M, Bravo IG, Momburg F, Alonso A, Tomakidi P (2007) The E5 protein of the human papillomavirus type 16 down-regulates HLA-I surface expression in calnexin-expressing but not in calnexin-deficient cells. Virology Journal 4: 116 doi

Piuko K, Bravo IG, Muller M (2007) Identification and characterization of equine granzyme b. Veterinary Immunology and Immunopathology 118: 239-251 doi

Reglero A, Bravo IG, Fernandez-Martinez V (2007) Sialic acids: ocurrence, metabolism and biological function. Anales De La Real Academia Nacional De Farmacia 73: 833-871

Bastone P, Bravo IG, Lochelt M (2006) Feline foamy virus-mediated marker gene transfer: identification of essential genetic elements and influence of truncated and chimeric proteins. Virology 348: 190-199 doi

Garcia-Vallve S, Iglesias-Rozas JR, Alonso A, Bravo IG (2006) Different papillomaviruses have different repertoires of transcription factor binding sites: convergence and divergence in the upstream regulatory region. BMC Evolutionary Biology 6: 20 doi

Schmitt M, Bravo IG, Snijders PJF, Gissmann L, Pawlita M, Waterboer T (2006) Bead-based multiplex genotyping of human papillomaviruses. Journal of Clinical Microbiology 44: 504-512 doi

Bravo IG, Crusius K, Alonso (2005) The E5 protein of the human papillomavirus type 16 modulates composition and dynamics of membrane lipids in keratinocytes. Archives of Virology 150: 231-246 doi

Garcia-Vallve S, Alonso A, Bravo IG (2005) Papillomaviruses: different genes have different histories. Trends in Microbiology 13: 514-521 doi

Villar-Suarez V, Colaco B, Calles-Venal I, Bravo IG, Fernandez-Alvarez JG, Fernandez-Caso M, Villar-Lacilla JM (2005) Effects of extracellular matrix on the morphology and behaviour of rabbit auricular chondrocytes in culture. Journal of Biomedicine and Biotechnology : 364-373 doi

Bravo IG, Alonso (2004) Mucosal human papillomaviruses encode four different E5 proteins whose chemistry and phylogeny correlate with malignant or benign growth. Journal of Virology 78: 13613-13626 doi

Bravo IG, Garcia-Vallve S, Romeu A, Reglero (2004) Prokaryotic origin of cytidylyltransferases and alpha-ketoacid synthases. Trends in Microbiology 12: 120-128 doi

Mao XH, Bravo IG, Cheng H, Alonso (2004) Multiple independent kinase cascades are targeted by hyperosmotic stress but only one activates stress kinase p38. Experimental Cell Research 292: 304-311 doi

Villar-Suarez V, Calles-Venal I, Bravo IG, Fernandez-Alvarez JG, Fernandez-Caso M, Villar-Lacilla JM (2004) Differential behavior between isolated and aggregated rabbit auricular chondrocytes on mastic surfaces. Journal of Biomedicine and Biotechnology : 86-92 doi Villar-Suarez V, Calles-Venal I, Bravo IG, Fernandez-Alvarez JG, Fernandez-Caso M, Villar-Lacilla JM (2004) Differential behavior between isolated and aggregated rabbit auricular chondrocytes on mastic surfaces. Journal of Biomedicine and Biotechnology : Pii s1110724304312039 doi

del Moral PG, Diez MT, Resines JA, Bravo IG, Arin MJ (2003) Simultaneous measurements of creatinine and purine derivatives in ruminant's urine using ion-pair hplc. Journal of Liquid Chromatography & Related Technologies 26: 2961-2968 doi

Revilla-Nuin B, Reglero A, Martinez-Blanco H, Bravo IG, Ferrero MA, Rodriguez-Aparicio LB (2002) Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Letters 511: 97-101 doi

Alonso JR, Brinon JG, Crespo C, Bravo IG, Arevalo R, Aijon J (2001) Chemical organization of the macaque monkey olfactory bulb: ii. Calretinin, calbindin D-28k, parvalbumin, and neurocalcin immunoreactivity. Journal of Comparative Neurology 432: 389-407 doi

Bravo IG, Barrallo S, Ferrero MA, Rodriguez-Aparicio LB, Martinez-Blanco H, Reglero (2001) Kinetic properties of the acylneuraminate cytidylyltransferase from Pasteurella haemolytica a2. Biochemical Journal 358: 585-598

Bravo IG, Busto F, De Arriaga D, Ferrero MA, Rodriguez-Aparicio LB, Martinez-Blanco H, Reglero (2001) A normalized plot as a novel and time-saving tool in complex enzyme kinetic analysis. Biochemical Journal 358: 573-583

Solana S, Reglero A, Martinez-Blanco H, Revilla-Nuin B, Bravo IG, Rodriguez-Aparicio LB, Ferrero M (2001) N-acetylneuraminic acid uptake in Pasteurella (mannheimia) haemolytica A2 occurs by an inducible and specific transport system. FEBS Letters 509: 41-46 doi

Brinon JG, Martinez-Guijarro FJ, Bravo IG, Arevalo R, Crespo C, Okazaki K, Hidaka H, Aijon J, Alonso JR (1999) Coexpression of neurocalcin with other calcium-binding proteins in the rat main olfactory bulb. Journal of Comparative Neurology 407: 404-414 doi

Brinon JG, Arevalo R, Crespo C, Bravo IG, Okazaki K, Hidaka H, Aijon J, Alonso JR (1998) Neurocalcin immunoreactivity in the rat main olfactory bulb. Brain Research 795: 204-214 doi

Bravo IG, Arevalo R, Crespo C, Porteros A, Brinon JG, Aijon J, Alonso JR (1996) NADPH-diaphorase activity in glial cells of nonfixed tissue. Journal of Physiology-London 493P: S40-S41

Crespo C, Arevalo R, Brinon JG, Porteros A, Bravo IG, Aijon J, Alonso JR (1996) Colocalization of NADPH-diaphorase and acetylcholinesterase in the rat olfactory bulb (vol 9, pg 207, 1995). Journal of Chemical Neuroanatomy 10: 177-177

Crespo C, Arevalo R, Brinon JG, Porteros A, Bravo IG, Aijon J, Alonso JR (1995) Colocalization of NADPH-diaphorase and acetylcholinesterase in the rat olfactory-bulb. Journal of Chemical Neuroanatomy 9: 207-216 doi

Bravo IG, Bravo ME, Plate G, Merlez J, Arancibia (1984) The pharmacokinetics of cotrimoxazole sulfonamide in malnourished (marasmic) infants. Pediatric Pharmacology 4: 167-176

Bravo ME, Bravo IG (1981) Possible competition between vitamin-A and sulfamethoxypyridazine for binding-sites in plasma-proteins of rats. IRCS Medical Science-Biochemistry 9: 1112-1112